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Gestational Trophoblastic Disease

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As a group, gestational trophoblastic disease is typified by which of the following?

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a. Scant cytotrophoblast

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b. Perivillous fibrin deposition

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c. Villous mesenchymal hyperplasia

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d. Abnormal trophoblast proliferation

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As illustrated by differences seen here between invasive mole (A) and choriocarcinoma (B), hydatidiform moles as a group are differentiated histologically from other nonmolar neoplasms by the presence of which of the following?

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A. Used with permission from Dr. Ona Faye-Peterson. B. Reproduced with permission from Schorge JO: Gestational trophoblastic disease. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 37-8.

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a. Villi

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b. Cytotrophoblast

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c. Syncytiotrophoblast

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d. Marked angiogenesis

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Gestational trophoblastic neoplasia includes all EXCEPT which of the following?

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a. Invasive mole

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b. Choriocarcinoma

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c. Partial hydatidiform mole

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d. Placental site trophoblastic tumor

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Which of the following histological changes, as shown here, are characteristic of hydatidiform moles?

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Used with permission from Dr. Y. Erika Fong. Reproduced with permission from Schorge JO: Gestational trophoblastic disease. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 37-1B.

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a. Chronic villitis and villous inclusion bodies

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b. Villous mesenchymal hyperplasia and acute villitis

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c. Villous lymphocytic infiltrates and syncytial knots

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d. Trophoblast proliferation and villous stromal edema

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A predominant maternal risk factor for molar pregnancy includes which of the following?

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a. Advanced maternal age

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b. Prior cesarean delivery

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c. Type 2 diabetes mellitus

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d. African American ethnicity

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