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Endocrine Disorders

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Which of the following is true of thyroid-stimulating hormone (TSH) during pregnancy?

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a. Decreased levels are found in early pregnancy.

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b. TSH crosses the placenta and stimulates fetal thyroxine production.

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c. TSH levels are increased in early pregnancy because of the effects of human chorionic gonadotropin (hCG).

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d. None of the above

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Maternal sources account for what percentage of fetal thyroxine at term?

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a. 10%

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b. 30%

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c. 50%

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d. 70%

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In a study of more than 1000 women with thyroid peroxidase (TPO) antibodies, there was an associated increased risk of which of the following?

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a. Placenta previa

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b. Preterm delivery

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c. Placental abruption

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d. Preterm rupture of membranes

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Which clinical symptom is not characteristic of mild thyrotoxicosis?

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a. Thyromegaly

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b. Tachycardia

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c. Cold intolerance

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d. Poor maternal weight

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The condition shown here is commonly associated with which of the following maternal signs?

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a. Tachycardia

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b. Enophthalmos

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c. Maternal androgen insensitivity

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d. All of the above

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The following fetal condition is associated with fetal thyrotoxicosis. If identified antenatally, the mother may be treated with which of the following agents, which is subsequently transported transplacentally to the fetus?

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Reproduced with permission from Cunningham FG, Leveno KJ, Bloom SL, et al (eds): Endocrine disorders. In Williams Obstetrics, 24th ed. New York, McGraw-Hill, 2014, Figure 58-2.

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a. Iodine

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