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Connective-Tissue Disorders

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All EXCEPT which of the following disorders are acquired connective tissue disorders?

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a. Rheumatoid arthritis

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b. Osteogenesis imperfecta

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c. Systemic lupus erythematosus

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d. Antiphospholipid antibody syndrome

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Which of the following statements is true regarding immune-mediated connective tissue disorders?

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a. They typically have no renal involvement.

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b. They have a clearly elucidated pathogenesis.

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c. They are always associated with rheumatoid factor.

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d. They may or may not have an association with autoantibody formation.

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How should a patient with a connective-tissue disorder be counseled regarding disease activity during pregnancy?

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a. It will worsen.

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b. It will improve.

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c. It will be unchanged.

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d. It will be modulated by the effect of pregnancy hormones.

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A patient presents with photosensitivity and the rash seen here. What is the best screening test for systemic lupus erythematosus?

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a. Anti-Smith antibody

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b. Antinuclear antibody

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c. Antiphospholipid antibody

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d. Anti-double-stranded-DNA antibody

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How early can fetal cells and free fetal DNA be detected in maternal blood?

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a. 1st trimester

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b. 2nd trimester

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c. 3rd trimester

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d. Puerperium

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The “autoimmunity gene,” which predisposes to lupus, rheumatoid arthritis, and Crohn disease, is located on what chromosome?

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a. Chromosome 6

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b. Chromosome 16

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c. Chromosome 21

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d. Chromosome 22

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