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Amenorrhea

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Which of the following clinical scenarios meets the definition of amenorrhea?

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a. 12-year-old with Tanner stage I breast development

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b. 16-year-old with Tanner stage II breast development

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c. 14-year-old with Tanner stage III breast development

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d. 18-year-old with Tanner stage V breast development and cessation of menses for the last two cycles

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Inhibin inhibits synthesis and secretion of which of the following hormones?

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a. Luteinizing hormone (LH)

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b. Follicle-stimulating hormone (FSH)

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c. Corticotropin-releasing hormone (CRH)

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d. Gonadotropin-releasing hormone (GnRH)

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Which of the following hormones can have a negative as well as a positive feedback at the level of the pituitary?

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a. Cortisol

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b. Oxytocin

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c. Estradiol

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d. Progesterone

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Which of the following hormones “rescues” the corpus luteum from luteolysis?

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a. Luteinizing hormone (LH)

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b. Human placental lactogen (hPL)

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c. Follicle-stimulating hormone (FSH)

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d. Human chorionic gonadotropin (hCG)

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Which of the following conditions is considered the most frequent cause of primary amenorrhea?

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a. Turner syndrome

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b. Asherman syndrome

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c. Androgen insensitivity syndrome

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d. Mayer-Rokitansky-Küster-Hauser syndrome

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An 18-year-old nulligravid female presents with primary amenorrhea. During examination, Tanner stage IV breast development and sparse pubic and axillary hair are noted. Also, a blind-ending vagina is identified. What is the likely diagnosis in this patient?

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a. Müllerian agenesis

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b. Premature ovarian failure

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c. Androgen insensitivity syndrome

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d. Congenital adrenal hyperplasia (CAH)

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