Principles of Chemotherapy
Compared with normal cells within the same tissue, tumor cells have which characteristic that leaves them more vulnerable to chemotherapy?
a. Greater cell membrane permeability
b. Faster completion of the cell cycle
c. Slower completion of the cell cycle
d. A greater percentage of cells progressing through the cell cycle
Cells in which phase of the cell cycle are LEAST sensitive to chemotherapeutic agents?
Reproduced, with permission, from Nguyen PD: Principles of Radiation Therapy. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 28-8.
Which of the following tumor qualities decreases a tumor's susceptibility to chemotherapy?
d. No gross residual disease after debulking surgery
Which term is used to describe drugs that can kill at several cell cycle phases?
d. Cell cycle nonspecific
Which term is used to describe chemotherapy used as primary treatment of advanced malignancy when no feasible alternative treatment exists?
Which term is used to describe chemotherapy used preoperatively to decrease the extent of subsequent resection?