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Principles of Chemotherapy

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Compared with normal cells within the same tissue, tumor cells have which characteristic that leaves them more vulnerable to chemotherapy?

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a. Greater cell membrane permeability

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b. Faster completion of the cell cycle

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c. Slower completion of the cell cycle

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d. A greater percentage of cells progressing through the cell cycle

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Cells in which phase of the cell cycle are LEAST sensitive to chemotherapeutic agents?

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Reproduced, with permission, from Nguyen PD: Principles of Radiation Therapy. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 28-8.

Graphic Jump Location
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a. S

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b. G0

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c. G1

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d. G2

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Which of the following tumor qualities decreases a tumor's susceptibility to chemotherapy?

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a. Metastatic lesion

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b. Slow doubling time

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c. High growth fraction

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d. No gross residual disease after debulking surgery

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Which term is used to describe drugs that can kill at several cell cycle phases?

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a. Omnicyclic

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b. Generational

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c. Broad spectrum

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d. Cell cycle nonspecific

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Which term is used to describe chemotherapy used as primary treatment of advanced malignancy when no feasible alternative treatment exists?

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a. Salvage

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b. Adjuvant

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c. Induction

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d. Neoadjuvant

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Which term is used to describe chemotherapy used preoperatively to decrease the extent of subsequent resection?

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a. Salvage

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b. Adjuvant

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c. Induction

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