What is a woman's lifetime risk of developing uterine cancer in the United States?
Which of the following does not increase a woman's risk of developing endometrial cancer?
What is the primary mechanism by which obesity increases the risk of endometrial cancer?
a. Androstenedione is aromatized by adipose tissue to estrone.
b. Androstenedione is aromatized by adipose tissue to estradiol.
c. Higher levels of insulin-like growth factor lead to anovulation, which results in unopposed estrogen.
What is the most common genetic syndrome associated with endometrial cancer?
b. Hereditary nonpolyposis colorectal cancer (HNPCC)
c. Hereditary breast ovarian cancer syndrome (BRCA1/BRCA2)
d. Cowden syndrome (phosphatase and tensin homolog [PTEN] mutation)
A 60-year-old woman has abnormal uterine bleeding. A transvaginal ultrasound reveals a 15-mm endometrial stripe and an 8-cm solid right adnexal mass. An office endometrial biopsy shows grade 1 endometrioid adenocarcinoma of the uterus. What is the most likely diagnosis?
a. Endometrial cancer metastatic to the ovary
b. Synchronous ovarian and endometrial cancer
c. Pedunculated leiomyoma and endometrial cancer
d. Ovarian granulosa cell tumor and endometrial cancer
Which of the following is appropriate treatment of a 35-year-old woman with the diagnosis of complex hyperplasia without atypia?
a. Medroxyprogesterone acetate
b. Combination oral contraceptive pills