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Endometrial Cancer

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What is a woman's lifetime risk of developing uterine cancer in the United States?

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a. 1 in 8

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b. 1 in 20

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c. 1 in 38

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d. 1 in 77

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Which of the following does not increase a woman's risk of developing endometrial cancer?

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a. Obesity

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b. Smoking

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c. Tamoxifen

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d. Unopposed estrogen

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What is the primary mechanism by which obesity increases the risk of endometrial cancer?

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a. Androstenedione is aromatized by adipose tissue to estrone.

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b. Androstenedione is aromatized by adipose tissue to estradiol.

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c. Higher levels of insulin-like growth factor lead to anovulation, which results in unopposed estrogen.

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d. None of the above

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What is the most common genetic syndrome associated with endometrial cancer?

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a. Li-Fraumeni syndrome

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b. Hereditary nonpolyposis colorectal cancer (HNPCC)

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c. Hereditary breast ovarian cancer syndrome (BRCA1/BRCA2)

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d. Cowden syndrome (phosphatase and tensin homolog [PTEN] mutation)

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A 60-year-old woman has abnormal uterine bleeding. A transvaginal ultrasound reveals a 15-mm endometrial stripe and an 8-cm solid right adnexal mass. An office endometrial biopsy shows grade 1 endometrioid adenocarcinoma of the uterus. What is the most likely diagnosis?

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a. Endometrial cancer metastatic to the ovary

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b. Synchronous ovarian and endometrial cancer

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c. Pedunculated leiomyoma and endometrial cancer

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d. Ovarian granulosa cell tumor and endometrial cancer

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Which of the following is appropriate treatment of a 35-year-old woman with the diagnosis of complex hyperplasia without atypia?

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a. Medroxyprogesterone acetate

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b. Combination oral contraceptive pills

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