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Epithelial Ovarian Cancer

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What percentage of epithelial ovarian cancers are hereditary?

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a. 1

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b. 10

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c. 15

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d. 20

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Which of the following is not a risk factor for ovarian cancer?

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a. Nulliparity

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b. Late menopause

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c. Combination oral contraceptive pill use

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d. Hereditary nonpolyposis colon cancer (HNPCC)

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Which of the following genetic mutations is associated with the highest risk of developing ovarian cancer?

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a. Phosphatase and tensin homolog (PTEN)

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b. Hereditary Breast Ovarian Cancer Syndrome 1 (BRCA1)

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c. Hereditary Breast Ovarian Cancer Syndrome 2 (BRCA2)

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d. MutL homolog 1, colon cancer, nonpolyposis type 2 (MLH1)

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A 40-year-old woman with a BRCA1 mutation undergoes a laparoscopic bilateral salpingo-oophorectomy (BSO) for risk reduction. By what percentage is her breast cancer risk reduced by her BSO?

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a. 25

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b. 50

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c. 75

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d. 90

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What is the main histologic difference between a low malignant potential tumor and epithelial ovarian cancer?

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a. Stromal invasion

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b. Mitotic activity

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c. Degree of nuclear atypia

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d. Nuclear-to-cytoplasmic ratio

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A 55-year-old healthy woman undergoes exploration for a large pelvic mass (shown below). Frozen section analysis of her right ovary notes “mucinous low malignant potential, cannot exclude invasion.” There is no other obvious disease. What surgical procedures should be performed, in addition to total abdominal hysterectomy and bilateral salpingo-oophorectomy?

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a. Pelvic washings, omentectomy, multiple peritoneal biopsies

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b. Pelvic washings, omentectomy, ...

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