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Ovarian Germ Cell and Sex Cord-Stromal Tumors

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What percentage of all ovarian cancers are germ cell and sex cord-stromal tumors?

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a. 1

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b. 10

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c. 20

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d. 30

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Which of the following is the most commonly diagnosed International Federation of Gynecology and Obstetrics (FIGO) stage for women with germ cell tumors?

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a. I

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b. II

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c. III

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d. IV

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What is the most common presenting symptom in a woman with a germ cell tumor?

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a. Bloating

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b. Abdominal pain

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c. Abdominal distention

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d. Menstrual abnormality

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Which of the following is not a tumor marker for germ cell tumors?

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a. Inhibin

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b. Alpha-fetoprotein (AFP)

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c. Lactate dehydrogenase (LDH)

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d. Human chorionic gonadotropin (hCG)

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Which of the following is the most commonly diagnosed ovarian malignancy during pregnancy?

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a. Dysgerminoma

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b. Choriocarcinoma

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c. Immature teratoma

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d. Granulosa cell tumor

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A 19-year-old female college student is diagnosed with a pelvic mass and an elevated lactate dehydrogenase (LDH) level. She reports that she was amenorrheic until she started taking combination oral contraceptive pills (COCs). She undergoes surgical exploration, and frozen section analysis of the surgical specimen reveals ovarian dysgerminoma. Which of the following is FALSE?

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a. Her karyotype is most likely 46,XX.

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b. Regardless of stage, she has an excellent prognosis.

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c. Her other ovary may contain a gonadoblastoma and should be removed.

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d. She should undergo complete surgical staging, but her uterus may be preserved.

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