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Principles of Chemotherapy

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In which phase of the cell cycle, do protein synthesis, RNA synthesis, and DNA repair occur?

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a. M

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b. S

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c. Gap 1 (G1)

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d. Gap 2 (G2)

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Compared with normal cells within the same tissue, tumor cells have which characteristic that leaves them more vulnerable to chemotherapy?

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a. Greater cell membrane permeability

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b. Faster completion of the cell cycle

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c. Slower completion of the cell cycle

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d. A greater percentage of cells in active phases of replication

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Which of the following tumors is LEAST susceptible to chemotherapy?

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a. Metastatic tumor

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b. Large primary tumor mass

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c. Nonpalpable, microscopic tumor

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d. Residual tumor after optimal surgical debulking

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Patients with an advanced malignancy and no feasible alternative treatment option can be treated with which type of chemotherapy?

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a. Salvage

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b. Adjuvant

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c. Induction

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d. Consolidation

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In what clinical scenario would consolidation chemotherapy be used?

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a. Treating recurrent disease

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b. Decreasing the extent of disease prior to surgical resection

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c. Preventing relapse after elimination of cancer with the initial therapy

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d. Destroying remaining microscopic cells present after primary tumor resection

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Which of the following is NOT a benefit of combination chemotherapy?

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a. Providing maximum cell kill

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b. Minimizing the emergence of drug resistance

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c. Decreasing adverse side effects and toxicities

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d. Increasing effectiveness in attacking heterogeneous populations of cells

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