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Cervical Cancer

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Which of the following statements regarding cervical cancer is NOT true?

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a. It is the most common gynecologic cancer in women worldwide.

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b. It is the second most common cancer diagnosed in women worldwide.

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c. In the Unites States, Hispanic women have the highest incidence rate.

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d. In the United States, African–American women have the highest mortality rate.

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Which human papillomavirus (HPV) subtype is most strongly associated with adenocarcinoma of the cervix?

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a. HPV 6

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b. HPV 16

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c. HPV 18

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d. HPV 31

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Which of the following is true regarding smoking and cervical cancer risk?

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a. Smoking may alter viral oncoprotein expression.

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b. Passive smoking increases the risk of cervical cancer.

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c. Women who smoke are less likely to clear high-risk human papillomavirus (HPV) infection.

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d. All of the above

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Which of the following statements regarding cervical cancer risk factors is FALSE?

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a. Cervical cancer is an acquired immune deficiency syndrome (AIDS)-defining illness.

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b. Transplant recipients have an increased risk of cervical cancer.

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c. In general, women who have an autoimmune disease and take immunosuppressant therapy do not have an increased risk of cervical cancer.

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d. Combination oral contraceptives are associated with an increased risk of cervical cancer due to the higher number of sexual partners in users.

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What does the human papillomavirus (HPV) oncogene E6 bind and inactivate, leading to immortalization of the cell?

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a. Rb

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b. p16

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c. p53

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d. Cyclin D1

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Which histologic subtype of cervical carcinoma is represented in this micrograph? Arrows point to keratin pearls.

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