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Gestational Trophoblastic Disease

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All of the following statements regarding gestational trophoblastic disease are true EXCEPT:

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a. The prognosis for most gestational trophoblastic neoplasia cases is poor.

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b. Gestational trophoblastic neoplasia typically develops after a molar pregnancy.

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c. Gestational trophoblastic neoplasia refers to a spectrum of tumors originating from the placenta.

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d. Gestational trophoblastic neoplasia refers to a subset of gestational trophoblastic disease that develops malignant sequelae.

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Epidemiologic factors that carry a higher risk of gestational trophoblastic disease include all of the following EXCEPT:

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a. Young maternal age

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b. Young paternal age

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c. Low dietary intake of carotene

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d. Native American living in the United States

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By what magnitude is the risk of molar pregnancy increased with a prior history of gestational trophoblastic disease?

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a. Twofold

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b. Fourfold

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c. Tenfold

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d. Risk not increased

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A 45-year-old G3P1A1 presents with a newly diagnosed pregnancy. She used oral contraceptives prior to conceiving. All of the following elements of her history place her at increased risk for gestational trophoblastic disease EXCEPT:

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a. Age

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b. Prior term pregnancy

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c. Use of oral contraceptives

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d. History of spontaneous abortion

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With regard to molar pregnancies, what does the term “androgenesis” refer to?

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a. Development of theca lutein cysts

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b. Absence of fetal tissue and amnion

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c. Development of a zygote that contains only maternal chromosomes

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d. Development of a zygote that contains only paternal chromosomes

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Which of the following features is NOT a characteristic of complete hydatidiform molar pregnancies (shown below)?

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Used with permission from Dr. Brian ...

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