Skip to Main Content

++

For the past 50 years, the incorporation of chemotherapy into the treatment of gynecologic cancers has perpetually evolved. New advances develop frequently and pose a continual challenge to staying abreast of the field. Thus, a foundation in this important third component of cancer treatment is essential.

++

In principle, chemotherapeutic drugs are able to treat cancer and spare normal cells by exploiting inherent differences in their individual growth patterns. Each tumor type has its own characteristics, which explain why the same chemotherapy regimen is not equally effective for the whole spectrum of gynecologic cancers. Selecting appropriate drugs and limiting toxicity demands an understanding of cellular kinetics and biochemistry.

++

The Cell Cycle

++

All dividing cells follow the same basic sequence for replication. The cell generation time is the time required to complete the five phases of the cell cycle (Fig. 27-1). The G1 phase (G = gap) involves various cellular activities, such as protein synthesis, RNA synthesis, and DNA repair. When prolonged, the cell is considered to be in the G0 phase, that is, the resting phase. G1 cells may either terminally differentiate into the G0 phase or reenter the cell cycle after a period of quiescence. During the S phase, new DNA is synthesized. The G2 (premitotic) phase is characterized by cells having twice the DNA content as they prepare for division. Finally, actual mitosis and chromosomal division takes place during the M phase.

++
Figure 27-1
Graphic Jump Location

Diagram of the cell cycle. Agents are organized according to the cell cycle stage in which they are most effective for tumor control.

++

Tumors do not typically have faster generation times, but instead have many more cells in the active phases of replication and have dysfunctional apoptosis, hence proliferation. In contrast, normal tissues have a much larger number of cells in the G0 phase. As a result, cancer cells proceeding through the cell cycle may be more sensitive to chemotherapeutic agents, whereas normal cells in G0 are protected. This growth pattern disparity underlies the effectiveness of chemotherapeutic agents.

++

Cancer Cell Growth

++

Tumors are characterized by a gompertzian growth pattern (Fig. 27-2). Fundamentally, a tumor mass requires progressively longer times to double in size as it enlarges. When a cancer is microscopic and nonpalpable, growth is exponential. However, as a tumor enlarges, the number of its cells undergoing replication decreases due to limitations in blood supply and increasing interstitial pressure.

++
Figure 27-2
Graphic Jump Location

The gompertzian growth curve. During early stages of tumor expansion, growth is exponential, but with enlargement, tumor growth slows. Consequently, most tumors have completed their exponential growth phase at the time of clinical detection.

++

When ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.