TY  - CHAP
M1  - Book, Section
TI  - First Trimester Screening for Aneuploidy
A1  - Bianchi, Diana W.
A1  - Crombleholme, Timothy M.
A1  - D'Alton, Mary E.
A1  - Malone, Fergal D.
PY  - 2015
T2  - Fetology: Diagnosis and Management of the Fetal Patient, 2e
AB  - Key  PointsNuchal  translucency  measurement  in  the  first  trimester  is  the  most  powerful  marker  for  fetal  Down  syndrome.Combination  of  nuchal  translucency  with  serum  markers  in  the  first  trimester  detects  up  to  87%  of  cases  of  Down  syndrome  for  a  5%  false-positive  rate.Septated  cystic  hygroma,  or  simple  nuchal  translucency  of  3.0  mm  or  greater,  are  indications  for  chorionic  villus  sampling  (CVS)  without  need  to  await  serum  marker  results.First  trimester  absence  of  the  nasal  bones,  reversal  of  flow  in  the  ductus  venosus,  and  tricuspid  regurgitation  may  have  a  limited  role  as  second-line  screening  tests  for  select  high-risk  patients  by  expert  sonologists.These  second-line  screening  tests  are  unlikely  to  have  any  value  for  routine  general  population  screening.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - obgyn.mhmedical.com/content.aspx?aid=1106395715
ER  -