TY  - CHAP
M1  - Book, Section
TI  - Overgrowth Syndromes
A1  - Bianchi, Diana W.
A1  - Crombleholme, Timothy M.
A1  - D'Alton, Mary E.
A1  - Malone, Fergal D.
PY  - 2015
T2  - Fetology: Diagnosis and Management of the Fetal Patient, 2e
AB  - Key  PointsGroup  of  conditions  characterized  by  generalized  excessive  growth  for  gestational  age.Incidence  between  1  in  10,000  and  1  in  15,000.Sonographic  findings  include  overgrowth,  polyhydramnios,  placentomegaly,  and  macroglossia.Differential  diagnosis  includes  incorrect  gestational  dating,  maternal  gestational  diabetes,  Sotos  syndrome,  Weaver  syndrome,  Beckwith–Wiedemann  syndrome,  and  Simpson–Golabi–Behmel  syndrome,  as  well  as  chromosome  abnormalities.Management  of  pregnancy  should  include  level  II  sonographic  examination,  high-resolution  karyotype,  and  molecular  testing  for  NSD1  and  GPC3  mutations.  If  these  tests  are  negative,  imprinting  disorders  of  11p15.5  should  be  tested.Newborn  treatment  should  include  medical  genetics  consultation,  cardiac  evaluation,  and  monitoring  for  hypoglycemia.Some  of  the  overgrowth  conditions  are  associated  with  a  predisposition  to  childhood  cancer.Several  of  the  overgrowth  conditions  have  Mendelian  patterns  of  inheritance.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - obgyn.mhmedical.com/content.aspx?aid=1106401569
ER  -