RT Book, Section
A1 Bianchi, Diana W.
A1 Crombleholme, Timothy M.
A1 D'Alton, Mary E.
A1 Malone, Fergal D.
SR Print(0)
ID 1106395765
T1 Second Trimester Screening for Aneuploidy
T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-144201-5
LK obgyn.mhmedical.com/content.aspx?aid=1106395765
RD 2024/04/19
AB Key  PointsQuad  marker  serum  screening  is  the  most  effective  form  of  Down  syndrome  screening  in  the  second  trimester  (81%  detection  rate  at  a  5%  false-positive  rate).Presence  of  a  major  structural  malformation  at  second  trimester  sonographic  fetal  anatomy  survey  is  an  indication  for  genetic  amniocentesis.A  range  of  minor  markers  at  second  trimester  sonographic  fetal  anatomy  survey  can  be  utilized  with  likelihood  ratios  to  adjust  the  risk  of  Down  syndrome.Absence  of  major  or  minor  markers  at  second  trimester  sonographic  fetal  anatomy  survey  reduces  the  risk  of  fetal  Down  syndrome  by  60%.Combinations  of  screening  tests  in  both  first  and  second  trimesters,  such  as  integrated,  stepwise,  and  contingency  screening,  may  be  more  efficient  than  screening  in  either  trimester  alone.