RT Book, Section
A1 Bianchi, Diana W.
A1 Crombleholme, Timothy M.
A1 D'Alton, Mary E.
A1 Malone, Fergal D.
SR Print(0)
ID 1106397694
T1 Esophageal Atresia and Tracheoesophageal Fistula
T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-144201-5
LK obgyn.mhmedical.com/content.aspx?aid=1106397694
RD 2024/04/25
AB Key  PointsOccurs  in  1  in  3000  livebirths.Fifty  percent  of  cases  have  associated  anomalies,  most  commonly  cardiac,  but  also  genitourinary,  anorectoal,  and  musculoskeletal.Sonographic  diagnosis  is  inferred  by  absence  of  the  fetal  stomach  with  polyhydramnios.Differential  diagnosis  includes  congenital  diaphragmatic  hernia,  situs  inversus,  and  musculoskeletal  or  neurologic  abnormalities.Chromosome  abnormalities  are  present  in  6%  to  10%  of  cases.  Fetal  karyotype  is  indicated.  Fetal  echocardiogram  should  be  performed.Delivery  is  not  mandated  at  a  tertiary  care  center.Long-term  outcome  may  be  complicated  by  esophagitis,  recurrent  strictures,  and  the  development  of  Barrett’s  mucosa.Mutations  in  the  genes  N-MYC,  CHD7,  and  SOX2,  which  cause  Feingold  syndrome,  CHARGE  syndrome,  and  anophthalmia,  esophageal  atresia,  and  genital  (AEG)  syndrome,  respectively,  are  important  genetic  causes  of  esophageal  atresia.