RT Book, Section
A1 Bianchi, Diana W.
A1 Crombleholme, Timothy M.
A1 D'Alton, Mary E.
A1 Malone, Fergal D.
SR Print(0)
ID 1106400563
T1 Ectrodactyly
T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-144201-5
LK obgyn.mhmedical.com/content.aspx?aid=1106400563
RD 2024/04/18
AB Key  PointsDevelopmental  malformation  that  consists  of  missing  digits,  a  deep  median  cleft,  and  fusion  of  remaining  digits.Occurs  as  either  a  nonsyndromic  split  hand/foot  malformation  or  as  a  syndromic  condition  with  associated  anomalies.Most  syndromic  ectrodactylies  are  inherited  as  autosomal  dominant  conditions  and  are  due  to  mutations  in  the  p63  gene.Incidence  is  1/18,000  in  newborns.Fetuses  with  ectrodactyly  should  be  referred  for  detailed  fetal  sonographic  anatomic  evaluation  due  to  the  high  incidence  of  associated  anomalies.Parents  should  be  examined  by  a  medical  geneticist  to  specifically  rule  out  subtle  malformations  such  as  missing  teeth.Fetal  karyotype  is  indicated.Intelligence  is  generally  normal  and  functional  outcome  of  the  hands  is  good  following  surgical  repair.