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Gestational Trophoblastic Disease

As a group, gestational trophoblastic disease is typified by which of the following?

a. Scant cytotrophoblast

b. Perivillous fibrin deposition

c. Villous mesenchymal hyperplasia

d. Abnormal trophoblast proliferation

As illustrated by differences seen here between invasive mole (A) and choriocarcinoma (B), hydatidiform moles as a group are differentiated histologically from other nonmolar neoplasms by the presence of which of the following?

A. Used with permission from Dr. Ona Faye-Peterson. B. Reproduced with permission from Schorge JO: Gestational trophoblastic disease. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 37-8.

a. Villi

b. Cytotrophoblast

c. Syncytiotrophoblast

d. Marked angiogenesis

Gestational trophoblastic neoplasia includes all EXCEPT which of the following?

a. Invasive mole

b. Choriocarcinoma

c. Partial hydatidiform mole

d. Placental site trophoblastic tumor

Which of the following histological changes, as shown here, are characteristic of hydatidiform moles?

Used with permission from Dr. Y. Erika Fong. Reproduced with permission from Schorge JO: Gestational trophoblastic disease. In Hoffman BL, Schorge JO, Schaffer JI, et al (eds): Williams Gynecology, 2nd ed. New York, McGraw-Hill, 2012, Figure 37-1B.

a. Chronic villitis and villous inclusion bodies

b. Villous mesenchymal hyperplasia and acute villitis

c. Villous lymphocytic infiltrates and syncytial knots

d. Trophoblast proliferation and villous stromal edema

A predominant maternal risk factor for molar pregnancy includes which of the following?

a. Advanced maternal age

b. Prior cesarean delivery

c. Type 2 diabetes mellitus

d. African American ethnicity

a. ...

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