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Connective-Tissue Disorders

All EXCEPT which of the following disorders are acquired connective tissue disorders?

a. Rheumatoid arthritis

b. Osteogenesis imperfecta

c. Systemic lupus erythematosus

d. Antiphospholipid antibody syndrome

Which of the following statements is true regarding immune-mediated connective tissue disorders?

a. They typically have no renal involvement.

b. They have a clearly elucidated pathogenesis.

c. They are always associated with rheumatoid factor.

d. They may or may not have an association with autoantibody formation.

How should a patient with a connective-tissue disorder be counseled regarding disease activity during pregnancy?

a. It will worsen.

b. It will improve.

c. It will be unchanged.

d. It will be modulated by the effect of pregnancy hormones.

A patient presents with photosensitivity and the rash seen here. What is the best screening test for systemic lupus erythematosus?

a. Anti-Smith antibody

b. Antinuclear antibody

c. Antiphospholipid antibody

d. Anti-double-stranded-DNA antibody

How early can fetal cells and free fetal DNA be detected in maternal blood?

a. 1st trimester

b. 2nd trimester

c. 3rd trimester

d. Puerperium

The “autoimmunity gene,” which predisposes to lupus, rheumatoid arthritis, and Crohn disease, is located on what chromosome?

a. Chromosome 6

b. Chromosome 16

c. Chromosome 21

d. Chromosome 22

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