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Cervical Cancer

Which of the following statements regarding cervical cancer is NOT true?

a. It is the most common gynecologic cancer in women worldwide.

b. It is the second most common cancer diagnosed in women worldwide.

c. In the Unites States, Hispanic women have the highest incidence rate.

d. In the United States, African–American women have the highest mortality rate.

Which human papillomavirus (HPV) subtype is most strongly associated with adenocarcinoma of the cervix?

a. HPV 6

b. HPV 16

c. HPV 18

d. HPV 31

Which of the following is true regarding smoking and cervical cancer risk?

a. Smoking may alter viral oncoprotein expression.

b. Passive smoking increases the risk of cervical cancer.

c. Women who smoke are less likely to clear high-risk human papillomavirus (HPV) infection.

d. All of the above

Which of the following statements regarding cervical cancer risk factors is FALSE?

a. Cervical cancer is an acquired immune deficiency syndrome (AIDS)-defining illness.

b. Transplant recipients have an increased risk of cervical cancer.

c. In general, women who have an autoimmune disease and take immunosuppressant therapy do not have an increased risk of cervical cancer.

d. Combination oral contraceptives are associated with an increased risk of cervical cancer due to the higher number of sexual partners in users.

What does the human papillomavirus (HPV) oncogene E6 bind and inactivate, leading to immortalization of the cell?

a. Rb

b. p16

c. p53

d. Cyclin D1

Which histologic subtype of cervical carcinoma is represented in this micrograph? Arrows point to keratin pearls.

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