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Gestational Trophoblastic Disease

All of the following statements regarding gestational trophoblastic disease are true EXCEPT:

a. The prognosis for most gestational trophoblastic neoplasia cases is poor.

b. Gestational trophoblastic neoplasia typically develops after a molar pregnancy.

c. Gestational trophoblastic neoplasia refers to a spectrum of tumors originating from the placenta.

d. Gestational trophoblastic neoplasia refers to a subset of gestational trophoblastic disease that develops malignant sequelae.

Epidemiologic factors that carry a higher risk of gestational trophoblastic disease include all of the following EXCEPT:

a. Young maternal age

b. Young paternal age

c. Low dietary intake of carotene

d. Native American living in the United States

By what magnitude is the risk of molar pregnancy increased with a prior history of gestational trophoblastic disease?

a. Twofold

b. Fourfold

c. Tenfold

d. Risk not increased

A 45-year-old G3P1A1 presents with a newly diagnosed pregnancy. She used oral contraceptives prior to conceiving. All of the following elements of her history place her at increased risk for gestational trophoblastic disease EXCEPT:

a. Age

b. Prior term pregnancy

c. Use of oral contraceptives

d. History of spontaneous abortion

With regard to molar pregnancies, what does the term “androgenesis” refer to?

a. Development of theca lutein cysts

b. Absence of fetal tissue and amnion

c. Development of a zygote that contains only maternal chromosomes

d. Development of a zygote that contains only paternal chromosomes

Which of the following features is NOT a characteristic of complete hydatidiform molar pregnancies (shown below)?

Used with permission from Dr. Brian ...

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