This book is dedicated to Mortimer G. Rosen, friend and mentor, whose early research on the fetal brain was an inspiration to me and many other young researchers struggling to understand the fetal brain. By creating the necessary clinical and scientific environment for such studies, he became very much a part of its “birth.” Many years ago, probably at the beginning of his career as a perinatologist, Dr. Rosen recognized the importance of studying the human fetal brain. Surrounded by a growing group of enthusiastic scholars, including residents, maternal-fetal fellows, biomedical engineers, and biochemists, he pursued his research on one of the most difficult subjects: the physiology and the physiopathology of the fetal central nervous system.
Dr. Rosen believed that the then available systems for monitoring fetal health and well-being were inadequate for predicting the intellectual functioning of the neonatal brain. He was always seeking new ways for studying the developing human brain.
When ultrasonography was introduced, Dr. Rosen was among the first to encourage its use in the study of fetal behavioral studies. When he saw the first detailed, crystal clear pictures of the prenatal central nervous system achieved by high frequency transvaginal imaging, he immediately understood the enormous potential of this laboratory technique.
His scientific integrity and skepticism stimulated us to become experts in our field, and furnish objective results to prove the clinical value of high resolution brain scanning of the fetus.
When I presented him with the outline of this book, he was not only supportive, but promised to contribute a special chapter on cerebral palsy, a subject in which he was extremely interested. This is the only time he let us down. The chapter never got further than its introduction. Mort Rosen—my mentor and friend, as well as enthusiastic supporter of our endeavors—passed away in 1992, not living long enough to see the fruits of his labors.
To you, Mort Rosen, in loving memory. I think you would be proud of this work.
Ilan E. Timor-Tritsch, MD
Ilan E. Timor-Tritsch, MD
To my family: my son, Benjamin; my parents, Edith and Miguel; my sister, my niece, and my brother-in-law: Edith A, Carolinna, and Michael who inspired, supported, and encouraged me.
To my wife and my daughter. Antonella and Isabella, you have all my love.
To papá y mamá with love, you will be in my heart forever. To Eyal, Andrés y Nicole, I am very proud of you. To Patricia, you make everything possible.