TY - CHAP M1 - Book, Section TI - Hypertelorism A1 - Bianchi, Diana W. A1 - Crombleholme, Timothy M. A1 - D'Alton, Mary E. A1 - Malone, Fergal D. PY - 2015 T2 - Fetology: Diagnosis and Management of the Fetal Patient, 2e AB - Key PointsDefined as an increased distance between inner and outer canthi.Prenatal sonographic measurements are obtained from either the outer-to-outer or inner-to-inner bony orbital margins.Unknown incidence but rare.Main concern is its association with median facial and/or brain defects as well as syndromes.Offer karyotype and FISH analysis for 22q11.2 deletion (associated with autosomal dominant form of Opitz syndrome).Prognosis depends on severity of associated anomalies and/or if a syndrome is present.DNA analysis is available for a number of the single-gene disorders associated with hypertelorism. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1106397011 ER -