TY  - CHAP
M1  - Book, Section
TI  - Ectrodactyly
A1  - Bianchi, Diana W.
A1  - Crombleholme, Timothy M.
A1  - D'Alton, Mary E.
A1  - Malone, Fergal D.
PY  - 2015
T2  - Fetology: Diagnosis and Management of the Fetal Patient, 2e
AB  - Key  PointsDevelopmental  malformation  that  consists  of  missing  digits,  a  deep  median  cleft,  and  fusion  of  remaining  digits.Occurs  as  either  a  nonsyndromic  split  hand/foot  malformation  or  as  a  syndromic  condition  with  associated  anomalies.Most  syndromic  ectrodactylies  are  inherited  as  autosomal  dominant  conditions  and  are  due  to  mutations  in  the  p63  gene.Incidence  is  1/18,000  in  newborns.Fetuses  with  ectrodactyly  should  be  referred  for  detailed  fetal  sonographic  anatomic  evaluation  due  to  the  high  incidence  of  associated  anomalies.Parents  should  be  examined  by  a  medical  geneticist  to  specifically  rule  out  subtle  malformations  such  as  missing  teeth.Fetal  karyotype  is  indicated.Intelligence  is  generally  normal  and  functional  outcome  of  the  hands  is  good  following  surgical  repair.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - obgyn.mhmedical.com/content.aspx?aid=1106400563
ER  -