TY - CHAP M1 - Book, Section TI - Polydactyly A1 - Bianchi, Diana W. A1 - Crombleholme, Timothy M. A1 - D'Alton, Mary E. A1 - Malone, Fergal D. PY - 2015 T2 - Fetology: Diagnosis and Management of the Fetal Patient, 2e AB - Key PointsDefined as the presence of a hand or foot with more than 5 digits.May be “radial/tibial” (formerly preaxial), “ulnar/fibular” (formerly postaxial), or “central”.Incidence is 1/100 to 1/698 depending on ethnic origin of population studied.Major consideration is to determine if isolated or associated with other anomalies. Isolated polydactyly is frequently inherited as an autosomal dominant condition.Polydactyly is a component of at least 119 recognized conditions.Differential diagnosis includes trisomy 13, Meckel–Gruber syndrome, Bardet-Biedl syndrome, Ellis–van Creveld syndrome, short-rib polydactyly syndrome, and Smith–Lemli–Opitz syndrome.Refer for detailed fetal sonographic anatomic evaluation, consider karyotype.Surgical outcome and prognosis are good if isolated.If associated with other anomalies, consider genetics consultation and DNA mutation testing.Recurrence risk depends on underlying diagnosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/19 UR - obgyn.mhmedical.com/content.aspx?aid=1106400606 ER -