TY - CHAP M1 - Book, Section TI - Preinvasive Disease of the Lower Genital Tract A1 - Downs, Levi S. A1 - Carter, Jori S. A2 - Karlan, Beth Y. A2 - Bristow, Robert E. A2 - Li, Andrew J. PY - 2015 T2 - Gynecologic Oncology: Clinical Practice and Surgical Atlas AB - Over the past 3 decades, the work of population scientists, laboratory-based researchers, and clinicians has together promoted the understanding of the pathogenesis of preinvasive disease of the lower genital tract and its associated cancers. Elucidating the progression from preinvasive disease to invasive cancer was the first step in implementing the Pap test as one of the most successful cancer screening program in developed nations and has dramatically lessened the impact of cervical cancer in the United States and other developed countries. Furthermore, with the identification of the human papillomavirus (HPV) as the principal and necessary cause of cervical cancer, the development and application of HPV vaccines will potentially further reduce the burden of cervical cancer and other HPV-induced malignancies. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/12/11 UR - obgyn.mhmedical.com/content.aspx?aid=1106569934 ER -