TY  - CHAP
M1  - Book, Section
TI  - Hematologic Malignancies in Pregnancy
A1  - Gergis, Usama
A1  - Desai, Pinkal
A1  - Rossi, Adriana
A1  - Phillips, Adrienne A.
A2  - Pacheco, Luis D.
A2  - Saade, George R.
A2  - Hankins, Gary D.V.
PY  - 2015
T2  - Maternal Medicine
AB  - The  spectrum  of  leukemia  in  humans  can  range  from  acute  to  chronic  leukemia.  Although  acute  leukemia  is  a  hematological  emergency  and  needs  treatment  urgently,  chronic  myeloid  leukemia  is  a  lifelong  illness  with  relatively  safe  targeted  therapies  requiring  indefinite  treatment.  Hematopoietic  stem  cell  transplantation  (HSCT)  is  an  important  component  of  treatment  for  acute  leukemia  and  the  only  chance  for  long-term  cure  for  a  certain  subset  of  patients  and  certainly  for  all  relapsed  patients.  Leukemia  in  pregnancy  is  challenging  in  terms  of  the  need  for  urgent  therapy  while  trying  to  preserve  fetal  viability  and  the  complexities  of  the  change  in  pharmacokinetics  and  pharmacodynamics  of  chemotherapy  in  the  pregnant  state.  Although  fertility  preservation  is  frequently  not  feasible  due  to  urgency  of  disease  state,  there  is  potential  for  planned  fertility  preservation  techniques  after  attaining  a  cure.  In  this  chapter,  we  discuss  the  unique  challenges  and  consequences  of  treatment  of  leukemia  and  effect  on  fertility  and  various  fertility  preservation  options  before  and  after  HSCT.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - obgyn.mhmedical.com/content.aspx?aid=1115521069
ER  -