TY - CHAP M1 - Book, Section TI - Maternal Sepsis A1 - Saade, George R. A2 - Foley, Michael R. A2 - Strong, Jr., Thomas H. A2 - Garite, Thomas J. PY - 2015 T2 - Obstetric Intensive Care Manual, 4e AB - Sepsis, severe sepsis, and septic shock are a continuum in the systemic response to infection. Sepsis is the leading cause of mortality in intensive care units and accounts for 10% of direct maternal deaths in North America. Most deaths in sepsis are due to multiple organ dysfunction syndrome (MODS), the final stage in the sepsis spectrum. The obstetric patient is particularly vulnerable to sepsis because of the association between pregnancy and infectious complications such as pyelonephritis, chorioamnionitis, endometritis, wound infection, necrotizing fascitis, and cholecystitis. Septic shock occurs in up to 4% of bacteremic patients, and 40% to 60% of patients in septic shock have bacteremia. The relationship between bacteremia and sepsis also depends on other contributing factors, such as immune suppression, and associated medical conditions. Overall, gram-negative aerobic bacilli used to be the predominant organisms associated with sepsis. However, the incidence of infection with gram-positive organisms in patients with sepsis has increased and may now equal that of gram-negative infections. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/03 UR - obgyn.mhmedical.com/content.aspx?aid=1115790664 ER -