TY - CHAP M1 - Book, Section TI - Maternal Sepsis A1 - Pacheco, Luis D. A1 - Saade, George R. A2 - Foley, Michael R. A2 - Strong, Jr, Thomas H. A2 - Garite, Thomas J. Y1 - 1 N1 - T2 - Obstetric Intensive Care Manual, 5e AB - Sepsis is the leading cause of mortality in intensive care units and accounts for 10% of direct maternal deaths in North America.* Most deaths in sepsis are due to multiple organ dysfunction. The obstetric patient is particularly vulnerable to sepsis because of the association between pregnancy and infectious complications such as pyelonephritis, chorioamnionitis, endometritis, wound infection, necrotizing fasciitis, and cholecystitis. Septic shock occurs in up to 4% of bacteremic patients, and 40% to 60% of patients in septic shock have bacteremia. The relationship between bacteremia and sepsis also depends on other contributing factors, such as immune suppression, and associated medical conditions. In obstetrical care, sepsis may be secondary to infections from viruses, fungi, gram-positive bacteria, gram-negative bacteria, and anaerobes. Importantly, positive cultures are not required to establish the diagnosis of sepsis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1152536908 ER -