TY  - CHAP
M1  - Book, Section
TI  - Management of a Vaso-Occlusive Sickle Cell Crisis in Pregnancy
A1  - Chambliss, Linda R.
A2  - Foley, Michael R.
A2  - Strong, Jr, Thomas H.
A2  - Garite, Thomas J.
Y1  - 1
N1  - 
T2  - Obstetric Intensive Care Manual, 5e
AB  - Hemoglobinopathies  are  inherited  disorders  that  result  in  abnormal  hemoglobin.  Broadly  speaking,  the  disorders  can  be  classified  as  disorders  of  the  quantity  of  hemoglobin  such  as  thalassemia  or  structural  disorders  such  as  sickle  cell  anemia.  Hemoglobinopathies  are  relatively  common  and  affect  about  5%  to  7%  of  the  world’s  popu­lation.  Sickle  cell  anemia  is  the  most  common  monogenic  disease.  The  prevalence  of  hemoglobinopathies  is  increasing  as  more  affected  children  survive  to  adulthood  and  subsequently  pass  on  the  genotype.  Approximately  300,000  children  are  born  worldwide  every  year  who  are  affected  with  sickle  cell  anemia.  The  prevalence  of  disease  is  high  in  Africa,  particularly  the  sub-Sahara,  but  also  in  areas  in  the  Mediterranean,  Middle  East,  and  India.  Sickle  cell  trait  occurs  in  about  1  in  8  African  Americans  and  about  1  in  600  African  Americans  have  sickle  cell  anemia.  A  variant  of  sickle  cell  anemia,  sickle-thalassemia  (HbSC)  is  seen  in  Middle  Easterners.  It  is  generally  milder  than  sickle  cell  anemia  but  may  present  for  the  time  in  pregnancy  which  is  why  it  is  important  to  obtain  a  hemoglobin  electrophoresis  in  the  evaluation  of  anemia  in  pregnancy.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - obgyn.mhmedical.com/content.aspx?aid=1152538461
ER  -