TY - CHAP M1 - Book, Section TI - Disorders of Prosencephalic Development: Holoprosencephaly A1 - Pilu, Gianluigi A1 - Malinger, Gustavo A2 - Malinger, Gustavo A2 - Monteagudo, Ana A2 - Pilu, Gianluigi A2 - Paladini, Dario A2 - Timor-Tritsch, Ilan E. Y1 - 2023 N1 - T2 - Timor's Ultrasonography of the Prenatal Brain, 4e AB - KEY POINTSHoloprosencephaly derives from failed or incomplete cleavage of the prosencephalon and is featured by varying degrees of fusion of the cerebral hemispheres, and has a very severe prognosis in most cases.It is frequently associated with other anomalies and genetic conditions.Prenatal sonographic diagnosis of the most severe forms that typically are found with severe craniofacial malformations and is usually straightforward since early gestation.Lesser degrees of anatomic alteration are associated with more subtle findings that may be difficult to recognize or categorize. SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/04/18 UR - obgyn.mhmedical.com/content.aspx?aid=1194695839 ER -