TY - CHAP M1 - Book, Section TI - Hirschsprung's Disease A1 - Bianchi, Diana W. A1 - Crombleholme, Timothy M. A1 - D'Alton, Mary E. A1 - Malone, Fergal D. Y1 - 2015 N1 - T2 - Fetology: Diagnosis and Management of the Fetal Patient, 2e AB - Key PointsOne of the most common causes of intestinal obstruction in the newborn. Characterized by severe constipation due to functional colonic obstruction with megacolon.Hirschsprung's disease rarely presents prenatally, but when it does it is usually due to total colonic aganglionosis.Sonographic features may include dilated loops of small intestine occasionally with enterolithiasis.About a quarter of affected patients have associated anomalies. There is a strong association with Down syndrome.Hirschsprung's disease diagnosed prenatally is at increased risk for syndromic associations by being long segment aganglionosis.Level II sonogram and antenatal karyotype are recommended.Diagnosis requires postnatal rectal biopsy to confirm aganglionosis.Treatment is a pull-through procedure to bring normal ganglionated bowel to the dentate line. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - obgyn.mhmedical.com/content.aspx?aid=1106399253 ER -