TY - CHAP M1 - Book, Section TI - Renal Agenesis A1 - Bianchi, Diana W. A1 - Crombleholme, Timothy M. A1 - D'Alton, Mary E. A1 - Malone, Fergal D. Y1 - 2015 N1 - T2 - Fetology: Diagnosis and Management of the Fetal Patient, 2e AB - Key PointsDevelopmental anomaly that occurs at 4 to 6 weeks of embryonic life.Incidence of bilateral renal agenesis is 1 in 3000 livebirths;for unilateral renal agenesis it is 1 in 500–1300 livebirths and higher in twins.Sonographic findings are severe oligohydramnios or anhydramnios occurring after 14 to 16 weeks in bilateral renal agenesis. In unilateral cases, the remaining kidney may be >95% in length for gestational age.Syndromes associated with bilateral renal agenesis are sirenomelia, caudal regression, branchio-oto-renal, cerebro-oculo-facial, Fraser, and Rokitansky–Kuster–Hauser. DiGeorge syndrome is also associated with unilateral renal agenesis.Consider amnioinfusion to obtain a karyotype.Most hereditary cases are inherited as an autosomal dominant condition with variable expressivity.Sonographic screening of the parental kidneys is recommended.Outcome is uniformly fatal for bilateral renal agenesis.For unilateral renal agenesis consider postnatal radionucleide scan, voiding cystourethrography, and prophylactic antibiotics. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1106399752 ER -