TY  - CHAP
M1  - Book, Section
TI  - Other Autosomal Aneuploidies
A1  - Bianchi, Diana W.
A1  - Crombleholme, Timothy M.
A1  - D'Alton, Mary E.
A1  - Malone, Fergal D.
Y1  - 2015
N1  - 
T2  - Fetology: Diagnosis and Management of the Fetal Patient, 2e
AB  - Key  PointsTrisomies  8,9,14,16,  and  20,  if  present  in  mosaic  form,  are  compatible  with  postnatal  survival.Mosaic  trisomies  are  generally  associated  with  nondisjunction  due  to  advanced  maternal  age.Trisomy  16  occurs  in  at  least  1.5%  of  all  clinically  recognized  pregnancies  and  31%  of  all  spontaneous  losses  due  to  chromosome  abnormalities.Trisomy  20  accounts  for  2%  oftrisomic  miscarriages  and  is  a  common  cause  oftrue  mosaicism  in  amniotic  fluid  cultures.For  mosaic  trisomies  8,9,  and  14,  a  detailed  sonographic  survey  of  fetal  anatomy  and  consultation  with  a  medical  geneticist  are  indicated.Women  carrying  fetuses  with  mosaic  trisomy  16  are  at  riskfor  developing  pre-eclampsia.Phenotype  does  not  correlate  with  percent  of  mosaic  cells  except  for  trisomy  20.  The  presence  of  more  than  60%  of  cells  with  trisomy  20  is  associated  with  a  poor  prognosis.All  continuing  pregnancies  should  have  involvement  of  the  medical  genetics  team.Survivors  with  trisomy  16  have  excellent  postnatal  catch-up  growth  and  the  majority  have  a  good  developmental  outcome.  Mosaic  trisomies  8,9,  and  14  have  variable  outcomes.  Mosaic  trisomy  20  has  a  normal  outcome  if  thereare  less  than  60%  abnormal  cells.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - obgyn.mhmedical.com/content.aspx?aid=1106402048
ER  -