TY - CHAP M1 - Book, Section TI - High-Grade Serous Carcinomas of the Ovary, Fallopian Tube, and Peritoneum A1 - Cohn, David E. A1 - Alvarez, Ronald D. A2 - Karlan, Beth Y. A2 - Bristow, Robert E. A2 - Li, Andrew J. Y1 - 2015 N1 - T2 - Gynecologic Oncology: Clinical Practice and Surgical Atlas AB - Epithelial ovarian, fallopian tube, and primary peritoneal cancers remain the most lethal of all the gynecologic malignancies. In 2010, approximately 21,880 women will be diagnosed with ovarian cancer in the United States; of these, 13,850 will be expected to die from this disease.1 Cancers arising from the fallopian tube and peritoneum are significantly less common that those arising from the ovarian epithelium, but share several similarities in their epidemiology, diagnosis, treatment, and associated outcomes. Because the vast majority of fallopian tube and primary peritoneal cancers exhibit a high-grade papillary serous histology, comparisons to similar disease in primary ovarian cancers suggest common molecular pathways that may promote carcinogenesis within the serous classification of these tumors. Several recent hypotheses also propose a fallopian tube origin for metastatic disease that would traditionally be considered as primary ovarian or peritoneal. Given the recent advances surrounding these diseases, this chapter considers this subset of high-grade serous reproductive cancers as a group, with specific differences highlighted. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1106570860 ER -