TY - CHAP M1 - Book, Section TI - Acute Fatty Liver of Pregnancy A1 - Jones, Megan A1 - McNulty, Jennifer A2 - Foley, Michael R. A2 - Strong, Jr, Thomas H. A2 - Garite, Thomas J. PY - 1 T2 - Obstetric Intensive Care Manual, 5e AB - Acute fatty liver of pregnancy (AFLP) is an uncommon but potentially fatal complication of pregnancy, which results in microvesicular fat deposition in the liver, resulting in severe liver dysfunction. Hallmarks of the disease include jaundice, coagulopathy, and encephalopathy. Although most commonly a disorder of the late third trimester, very rare cases have been reported as early as 23 weeks. The incidence of AFLP appears to have increased over the past 30 years (from 1:15,900 to 1:6692 deliveries), possibly as more widespread recognition of the disease and identification of milder cases occurs. Prior to the 1970s, maternal and fetal mortality rates were reported to be as high as 75% and 85%, respectively. However, recent reports suggest markedly improved maternal mortality, ranging from 0% to 10% and fetal mortality from 8% to 25%. Deaths have been attributed to bleeding complications, aspiration, renal failure, and sepsis. Survivors of AFLP generally recover without sequelae. Early diagnosis is critical and AFLP should be considered in all pregnant women presenting in the third trimester of pregnancy with nausea, vomiting, or epigastric pain. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1152537258 ER -