TY - CHAP M1 - Book, Section TI - Cardiomyopathy A1 - Bianchi, Diana W. A1 - Crombleholme, Timothy M. A1 - D'Alton, Mary E. A1 - Malone, Fergal D. PY - 2015 T2 - Fetology: Diagnosis and Management of the Fetal Patient, 2e AB - Key PointsGenerally classified as dilated or hypertrophic cardiomyopathy.Incidence is 1.2 per 100,000. Higher in males due to X-linked conditions.Most common causes of hypertrophic cardiomyopathy are maternal diabetes, twin–twin transfusion, Noonan syndrome, inborn error of metabolism, and familial single-gene disorder.Most common causes of dilated cardiomyopathy are infection, endocardial fibroelastosis, dysrhythmia, carnitine deficiency, and familial single-gene disorder.Associated with high incidence of antenatal cardiac dysfunction and in utero mortality (except if due to maternal diabetes).Twenty percent of cases are familial. Obtain a family history and consider evaluating both parents.As many as 40% of cases require postnatal heart transplant.Increasing numbers of causative mutations in genes for sarcomeric and cytoskeletal proteins have been identified. Most are inherited as autosomal dominant disorders with variable penetrance. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1106398426 ER -