TY - CHAP M1 - Book, Section TI - Neuroblastoma A1 - Bianchi, Diana W. A1 - Crombleholme, Timothy M. A1 - D'Alton, Mary E. A1 - Malone, Fergal D. PY - 2015 T2 - Fetology: Diagnosis and Management of the Fetal Patient, 2e AB - Key PointsMost common solid tumor in infants.Neuroblastomas are generally diagnosed by sonography in the third trimester, and can be cystic, solid, or both.The differential diagnosis includes hydronephrosis, multicystic kidney, obstructive duplex collecting system, Wilms’ tumor, mesoblastic nephroma, and adrenal hemorrhage.Neuroblastoma in situ may be responsible for many prenatally diagnosed cystic neuroblastomas, and may be due to delayed regression of neuroblasts.83% of prenatally diagnosed neuroblastomas will be localized stage I or II disease.Neuroblastoma is stage III or IVS in only 16% of cases.Poor prognostic signs, such as N-myc amplification, occur in less than 5% of cases.Prenatal complications such as fetal hydrops, hepatomegaly, and maternal hypertension occur rarely. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - obgyn.mhmedical.com/content.aspx?aid=1106401000 ER -