TY - CHAP M1 - Book, Section TI - Gestational Trophoblastic Disease A1 - Singh, Diljeet K. A2 - Karlan, Beth Y. A2 - Bristow, Robert E. A2 - Li, Andrew J. PY - 2015 T2 - Gynecologic Oncology: Clinical Practice and Surgical Atlas AB - Gestational trophoblastic disease (GTD) represents a spectrum of cellular proliferations arising from the villous trophoblast of the placenta and encompasses 4 clinicopathologic entities: hydatidiform mole (complete and partial), invasive mole, choriocarcinoma (CCA), and placental site trophoblastic tumor (PSTT). The last 3 conditions are associated with more significant clinical sequelae and together comprise the general term gestational trophoblastic neoplasia (GTN). In the absence of GTD, a normal pregnancy involves functioning trophoblast that invades the endometrium and recruits a robust vasculature to develop the placenta, which supports intrauterine fetal development. In healthy trophoblastic tissue, these "cancer simulating" behaviors are highly regulated; however, in GTD, normal control mechanisms fail, leading to invasive, vascular tumors with a tendency to metastasize.1 SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/28 UR - obgyn.mhmedical.com/content.aspx?aid=1106570459 ER -