RT Book, Section
A1 Pilu, Gianluigi
A1 Buyukkurt, Selim
A1 Malinger, Gustavo
A2 Timor-Tritsch, Ilan E.
A2 Monteagudo, Ana
A2 Pilu, Gianluigi
A2 Malinger, Gustavo
SR Print(0)
ID 1138379213
T1 ANOMALIES OF VENTRAL INDUCTION
T2 Ultrasonography of the Prenatal Brain, 3e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071613064
LK obgyn.mhmedical.com/content.aspx?aid=1138379213
RD 2024/04/25
AB KEY  POINTSAnomalies  of  ventral  induction  of  the  fetal  brain  include  a  group  of  conditions  that  share  in  common  an  anomalous  process  of  cleavage  of  the  brain  and  formation  of  midline  structures,  encompassing  a  wide  spectrum  of  severity.  They  are  frequently  associated  with  other  malformations  and  genetic  conditions.Holoprosencephaly  is  one  of  the  most  severe  disorders  of  ventral  induction;  it  features  incomplete  separation  of  the  cerebral  hemispheres  and  has  a  very  severe  prognosis  in  most  cases.Agenesis  of  the  corpus  callosum  is  either  complete  or  limited  to  the  posterior  portion;  the  anatomy  is  variable,  but  enlargement  of  the  lateral  ventricles  and  the  absence  of  the  cavity  of  the  septum  pellucidum  are  frequently  present.  The  prognosis  is  largely  influenced  by  the  the  association  with  other  anomalies;  isolated  agenesis  of  the  corpus  callosum  may  be  associated  with  a  normal  intellectual  development,  although  the  experience  is  limited.Agenesis  of  the  septum  pellucidum  is  frequently  a  part  of  other,  often  severe  malformations,  including  holoprosenephaly,  gross  hydrocephaly,  and  schizencephaly.  Isolated  agenesis  of  the  septum  pellucidum  may  be  a  normal  variant,  although  it  may  be  the  only  antenatal  finding  of  septo-optic  dysplasia,  a  condtiion  that  is  usually  associated  with  visual  impairment  and  endocrine  disfunction.