RT Book, Section A1 Chambliss, Linda R. A2 Foley, Michael R. A2 Strong, Jr, Thomas H. A2 Garite, Thomas J. SR Print(0) ID 1152538461 T1 Management of a Vaso-Occlusive Sickle Cell Crisis in Pregnancy T2 Obstetric Intensive Care Manual, 5e YR 1 FD 1 PB McGraw-Hill Education PP New York, NY SN 9781259861758 LK obgyn.mhmedical.com/content.aspx?aid=1152538461 RD 2024/03/28 AB Hemoglobinopathies are inherited disorders that result in abnormal hemoglobin. Broadly speaking, the disorders can be classified as disorders of the quantity of hemoglobin such as thalassemia or structural disorders such as sickle cell anemia. Hemoglobinopathies are relatively common and affect about 5% to 7% of the world’s popu­lation. Sickle cell anemia is the most common monogenic disease. The prevalence of hemoglobinopathies is increasing as more affected children survive to adulthood and subsequently pass on the genotype. Approximately 300,000 children are born worldwide every year who are affected with sickle cell anemia. The prevalence of disease is high in Africa, particularly the sub-Sahara, but also in areas in the Mediterranean, Middle East, and India. Sickle cell trait occurs in about 1 in 8 African Americans and about 1 in 600 African Americans have sickle cell anemia. A variant of sickle cell anemia, sickle-thalassemia (HbSC) is seen in Middle Easterners. It is generally milder than sickle cell anemia but may present for the time in pregnancy which is why it is important to obtain a hemoglobin electrophoresis in the evaluation of anemia in pregnancy.