RT Book, Section A1 Hoffman, Barbara L. A1 Schorge, John O. A1 Halvorson, Lisa M. A1 Hamid, Cherine A. A1 Corton, Marlene M. A1 Schaffer, Joseph I. SR Print(0) ID 1171662685 T1 Endometrial Cancer T2 Williams Gynecology, 4e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260456868 LK obgyn.mhmedical.com/content.aspx?aid=1171662685 RD 2024/10/10 AB In the United States, endometrial cancer is the most common gynecologic malignancy. Risk factors include obesity and advancing age. As these factors are now more prevalent, the incidence of endometrial cancer continues to rise. Fortunately, patients usually seek medical attention early due to vaginal bleeding, and endometrial biopsy leads quickly to diagnosis. The cornerstone of treatment is hysterectomy with bilateral salpingo-oophorectomy (BSO) and surgical staging that includes lymph node assessment for most women. Of affected women, 67 percent will have stage I disease that is potentially curable by surgery alone, although high-risk stage I patients often receive adjuvant therapy (Siegel, 2019). The 21 percent of patients with regional disease and 8 percent with distant disease typically require multimodality treatment that includes some combination of surgery, chemotherapy, and radiotherapy.