RT Book, Section
A1 Cunningham, F. Gary
A1 Leveno, Kenneth J.
A1 Dashe, Jodi S.
A1 Hoffman, Barbara L.
A1 Spong, Catherine Y.
A1 Casey, Brian M.
SR Print(0)
ID 1190769503
T1 Endocrine Disorders
T2 Williams Obstetrics, 26e
YR 2022
FD 2022
PB McGraw Hill
PP New York, NY
SN 9781260462739
LK obgyn.mhmedical.com/content.aspx?aid=1190769503
RD 2024/04/19
AB Endocrinopathies  are  closely  related  to  pregnancy  for  several  reasons.  One  example  is  the  gestational  proclivity  for  prodigious  hormone  secretion,  which  is  perhaps  best  illustrated  by  placental  lactogen  in  diabetes.  This  is  the  most  common  endocrinopathy  encountered  in  pregnancy  and  discussed  in  Chapter  57.  Pregnancy  is  also  interrelated  with  some  endocrinopathies  that  are  at  least  partially  due  to  autoimmune  dysregulation.  Clinical  manifestations  result  from  complex  interplay  among  genetic,  environmental,  and  endogenous  factors  that  activate  the  immune  system  against  targeted  cells  within  endocrine  organs.  In  one  extraordinary  interaction,  studies  have  implicated  maternal  organ  engraftment  by  fetal  cells  transferred  during  pregnancy.  These  cells  later  provoke  antibody  production,  tissue  destruction,  and  autoimmune  endocrinopathies.