RT Book, Section A1 Cunningham, F. Gary A1 Leveno, Kenneth J. A1 Dashe, Jodi S. A1 Hoffman, Barbara L. A1 Spong, Catherine Y. A1 Casey, Brian M. SR Print(0) ID 1190769664 T1 Connective Tissue Disorders T2 Williams Obstetrics, 26e YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781260462739 LK obgyn.mhmedical.com/content.aspx?aid=1190769664 RD 2024/10/10 AB Connective tissue disorders, also termed collagen vascular disorders, have two basic underlying causes. First are the immune-complex diseases, in which deposition of immune complexes causes connective tissue damage. Because these manifest by sterile inflammation—predominantly of the skin, joints, blood vessels, and kidneys—they are referred to as rheumatic diseases. Many of these immune-complex diseases are more prevalent in women, and systemic lupus erythematosus (SLE) and rheumatoid arthritis are examples. Second are the inherited disorders that involve bone, skin, cartilage, blood vessels, and basement membranes. These include Marfan syndrome, osteogenesis imperfecta, and Ehlers-Danlos syndrome.