RT Book, Section
A1 Malinger, Gustavo
A1 Har Toov, Joseph
A1 Ben-Sira, Liat
A1 Lerman-Sagie, Tally
A2 Malinger, Gustavo
A2 Monteagudo, Ana
A2 Pilu, Gianluigi
A2 Paladini, Dario
A2 Timor-Tritsch, Ilan E.
SR Print(0)
ID 1194696332
T1 Malformations of Cortical Development: Migration and Post Migration Disorders
T2 Timor's Ultrasonography of the Prenatal Brain, 4e
YR 2023
FD 2023
PB McGraw Hill Education
PP New York, NY
SN 9781260136166
LK obgyn.mhmedical.com/content.aspx?aid=1194696332
RD 2024/04/19
AB Key  PointsMigration  and  to  less  extent  organization  develop  during  fetal  life  but  are  rarely  diagnosed  in  low-risk  populations  due  to  late  development  of  the  sulcation  or  to  the  severity  of  associated  malformations.MCD’s  caused  by  a  mutation  in  a  single  gene  can  cause  an  extremely  wide  spectrum  of  disease  ranging  from  mild  neurological  or  developmental  deficits  to  severe  developmental  delay,  neuromotor  impairment,  intractable  convulsions  and  even  death  during  the  first  years  of  life.An  etiologic  imaging  diagnosis  is  usually  difficult  due  to  the  fact  that  in  some  cases  mutations  in  different  genes  produce  similar  signs.Patients  at  high  risk  of  abnormal  neuronal  migration  disorders  (Table  10–1)  need  a  dedicated  follow-up  whenever  possible  in  the  context  of  the  Fetal  Neurology  Clinic.These  patients  should  be,  ideally,  being  followed  by  repeated  neurosonographic  examinations  and  whenever  necessary  fetal  MRI.The  advancements  in  the  field  of  next  generation  sequencing  will  become,  in  the  near  future,  an  essential  part  of  the  initial  evaluation  of  these  fetuses.