RT Book, Section
A1 Paladini, Dario
A1 Birnbaum, Roee
A2 Malinger, Gustavo
A2 Monteagudo, Ana
A2 Pilu, Gianluigi
A2 Paladini, Dario
A2 Timor-Tritsch, Ilan E.
SR Print(0)
ID 1194721663
T1 Central Nervous System Involvement and Risk of Neurodevelopmental Delay in Fetuses with Congenital Heart Disease
T2 Timor's Ultrasonography of the Prenatal Brain, 4e
YR 2023
FD 2023
PB McGraw Hill Education
PP New York, NY
SN 9781260136166
LK obgyn.mhmedical.com/content.aspx?aid=1194721663
RD 2024/04/19
AB KEY  POINTSIt  is  well  established  that  congenital  heart  disease  (CHD)  in  general,  and  lesions  resulting  in  a  univentricular  circulation  in  particular,  are  associated  with  increased  risk  for  neurodevelopmental  impairments.Although  still  an  emerging  field  in  prenatal  diagnosis,  accumulating  data  shows  that  the  CHD  itself  is  responsible  for  brain  abnormalities  such  as  periventricular  leukomalacia  (PVL),  migration  abnormalities  or  biometric  problems.The  pathogenetic  mechanism  for  these  abnormalities  may  involve,  at  least  in  part,  hemodynamic  changes,  and  fetal  genetic  conditions.Neurosonography  is  indicated  in  fetuses  with  CHD,  in  order  to  rule  out  associated  CNS  malformations  (such  as  sulcation  and  gyration  abnormalities),  and/or  acquired  lesions.