RT Book, Section
A1 Li, Yunping
A2 Hess, Philip E.
A2 Li, Yunping
A2 Kowalczyk, John J.
A2 Stiles, Justin K.
SR Print(0)
ID 1199673302
T1 Dexmedetomidine
T2 Obstetric Anesthesia: Quick References & Practical Guides
YR 2023
FD 2023
PB McGraw Hill
PP New York, NY
SN 9781264671465
LK obgyn.mhmedical.com/content.aspx?aid=1199673302
RD 2024/04/18
AB Morphine,  fentanyl,  sufentanil,  and  epinephrine  have  been  widely  and  safely  used  as  adjuvants  for  labor  analgesia  and  for  cesarean  delivery  anesthesia.  An  introduction  of  alpha2-adrenergic  agonist  dexmedetomidine  (DEX)  in  obstetric  anesthesia  could  provide  the  unique  analgesic  benefit  without  side  effects  of  opioids  such  as  pruritus,  urinary  retention,  hyperalgesia,  and  respiratory  depression.  The  addition  of  DEX  to  neuraxial  local  anesthetics  produces  a  significant  prolongation  in  the  duration  of  sensory  and  motor  blockage  and  reduction  in  post  cesarean  opioid  requirement.1  Various  animal  studies  have  been  conducted  using  intrathecal  DEX  at  a  dose  range  of  2.5  to  100  μg  without  any  neurotoxicity,  similarly,  without  any  postoperative  neurological  deficit  in  human  studies.