RT Book, Section
A1 Bianchi, Diana W.
A1 Crombleholme, Timothy M.
A1 D'Alton, Mary E.
A1 Malone, Fergal D.
SR Print(0)
ID 1106396627
T1 Macrocephaly
T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-144201-5
LK obgyn.mhmedical.com/content.aspx?aid=1106396627
RD 2024/04/25
AB Key  PointsMacrocephaly  is  defined  as  a  head  circumference  greater  than  three  standard  deviations  (SDs)  above  the  mean  for  age  and  sex.This  disorder  is  rare,  and  the  exact  incidence  is  unknown.The  antenatal  natural  history  has  not  been  elucidated.During  the  antepartum  period,  other  causes  of  macrocephaly  should  be  excluded  such  as  hydrocephalus  or  intracranial  space-occupying  lesion.The  diagnosis  of  macrocephaly  should  not  alter  prenatal  care  with  regard  to  timing  of  delivery  or  mode  of  delivery.Long-term  outcome  regarding  macrocephaly  is  sparse.  The  majority  of  cases  appear  to  do  well;  however,  it  appears  to  be  associated  with  an  increased  risk  for  autism.  Unilateral  macrocephaly  seems  to  be  associated  with  poor  outcomes.The  inheritance  pattern  of  benign  macrocephaly  is  autosomal  dominant  with  incomplete  penetrance  with  a  male  to  female  preponderance  of  4:1.  Differential  diagnosis  should  include  consideration  of  overgrowth  syndromes,  which  may  be  due  to  single-gene  disorders.