RT Book, Section
A1 Bianchi, Diana W.
A1 Crombleholme, Timothy M.
A1 D'Alton, Mary E.
A1 Malone, Fergal D.
SR Print(0)
ID 1106397011
T1 Hypertelorism
T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-144201-5
LK obgyn.mhmedical.com/content.aspx?aid=1106397011
RD 2023/09/28
AB Key  PointsDefined  as  an  increased  distance  between  inner  and  outer  canthi.Prenatal  sonographic  measurements  are  obtained  from  either  the  outer-to-outer  or  inner-to-inner  bony  orbital  margins.Unknown  incidence  but  rare.Main  concern  is  its  association  with  median  facial  and/or  brain  defects  as  well  as  syndromes.Offer  karyotype  and  FISH  analysis  for  22q11.2  deletion  (associated  with  autosomal  dominant  form  of  Opitz  syndrome).Prognosis  depends  on  severity  of  associated  anomalies  and/or  if  a  syndrome  is  present.DNA  analysis  is  available  for  a  number  of  the  single-gene  disorders  associated  with  hypertelorism.