RT Book, Section A1 Bianchi, Diana W. A1 Crombleholme, Timothy M. A1 D'Alton, Mary E. A1 Malone, Fergal D. SR Print(0) ID 1106398659 T1 Omphalocele T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-144201-5 LK obgyn.mhmedical.com/content.aspx?aid=1106398659 RD 2024/10/14 AB Key PointsDefect in ventral abdominal wall characterized by absent abdominal muscles, fascia, and skin. Defect is covered by membrane that consists of peritoneum and amnion.Incidence 1 in 4000 to 1 in 7000 livebirths.Principal sonographic diagnostic feature is umbilical cord insertion into the membrane covering the defect at a location distant from the abdominal wall.Differential diagnosis includes gastroschisis, body-stalk anomalies, pentalogy of Cantrell, and Beckwith–Wiedemann syndrome.There is a high incidence of both associated malformations and chromosome abnormalities. Prenatal karyotype is indicated. Fetal echocardiogram is recommended.Serial prenatal sonograms should be performed to assess fetal growth and amniotic fluid volume.Delivery at a tertiary care center provides optimal care for the newborn. Mode of delivery is debatable, except for cases of giant omphalocele or extracorporeal liver, in which cesarean section should be performed.Even with primary surgical repair, prospective parents should anticipate a long hospitalization for their neonate.